Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 7/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | CPT2 | P23786 | 2/20 | 0.32 |
| ▸ | CPT1A | P50416 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20550594 | 1.00 | KDM4E (0.34) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL17778539 | 1.00 | KDM4E (0.34) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL17769474 | 1.00 | KDM4E (0.34) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL17778464 | 0.96 | TRPV1 (0.35) | KDM4EALDH1A1RAF1TRPV1CPT2 | |
| SCHEMBL20550333 | 0.96 | TRPV1 (0.35) | KDM4EALDH1A1RAF1TRPV1CPT2 | |
| SCHEMBL17769785 | 0.96 | TRPV1 (0.35) | KDM4EALDH1A1RAF1TRPV1CPT2 | |
| SCHEMBL20550591 | 0.93 | KIF18A (0.35) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL20550338 | 0.93 | KIF18A (0.35) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL20550336 | 0.93 | KIF18A (0.35) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL20550485 | 0.91 | KDR (0.35) | KDM4EALDH1A1CYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | KDM4E 1291/4885ALDH1A1 1067/4885CYP2C9 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.