Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 5/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 2/20 | 0.33 |
| ▸ | CPT1A | P50416 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20550336 | 1.00 | KIF18A (0.35) | KIF18AALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL20550591 | 1.00 | KIF18A (0.35) | KIF18AALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL17769731 | 0.96 | KIF11 (0.36) | KIF18AALDH1A1KDM4ERAF1KCNJ6 | |
| SCHEMBL17769566 | 0.96 | KIF11 (0.36) | KIF18AALDH1A1KDM4ERAF1KCNJ6 | |
| SCHEMBL17769729 | 0.96 | KIF11 (0.36) | KIF18AALDH1A1KDM4ERAF1KCNJ6 | |
| SCHEMBL20550593 | 0.93 | RAF1 (0.36) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL20550485 | 0.93 | KDR (0.35) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL17778497 | 0.93 | RAF1 (0.36) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL20550484 | 0.93 | KDR (0.35) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL20550380 | 0.93 | RAF1 (0.36) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | KIF18A 3189/4885ALDH1A1 1067/4885KDM4E 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.