Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805858 | 0.90 | PDPK1 (0.72) | PDPK1CYP2A6LOXL2KAT6APTGDR2 | |
| SCHEMBL16159287 | 0.86 | PDPK1 (0.67) | PDPK1CYP2A6LOXL2KAT6APTGDR2 | |
| SCHEMBL4425765 | 0.83 | PDPK1 (0.74) | PDPK1CYP2A6LOXL2KAT6APTGDR2 | |
| SCHEMBL22130295 | 0.82 | PDPK1 (0.67) | PDPK1CYP2A6LOXL2CLK4HDAC2 | |
| SCHEMBL30060874 | 0.80 | PDPK1 (0.58) | PDPK1CYP2A6LOXL2KAT6APTGDR2 | |
| SCHEMBL16159315 | 0.80 | PDPK1 (0.58) | PDPK1CYP2A6LOXL2KAT6ACYP19A1 | |
| SCHEMBL14961829 | 0.79 | CLK4 (0.61) | CYP2A6KAT6ACLK4DYRK1ACYP19A1 | |
| SCHEMBL12794006 | 0.79 | GP6 (0.58) | PDPK1CYP2A6 | |
| SCHEMBL16159534 | 0.79 | PDPK1 (0.61) | PDPK1CYP2A6LOXL2KAT6APTGDR2 | |
| SCHEMBL16159295 | 0.79 | PDPK1 (0.61) | PDPK1CYP2A6LOXL2KAT6APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414759-B2 | Phenylthiazoles and uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | TPMT, TST, CLPP | PDPK1 1592/4885CYP2A6 1175/4885LOXL2 1206/4885 |
| US-10414759-B2 | Phenylthiazoles and uses thereof | TPMT, TST, CLPP | PDPK1 1403/4885CYP2A6 1311/4885LOXL2 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.