Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13404359 | 0.83 | HDAC8 (0.42) | VCAM1HTTSMN1; SMN2LMNAMAPT | |
| SCHEMBL2055333 | 0.81 | CNR2 (0.51) | VCAM1SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL13434084 | 0.79 | MAPT (0.57) | VCAM1HTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL12115484 | 0.77 | KDM4E (0.52) | SMN1; SMN2LMNAALDH1A1POLB | |
| SCHEMBL28417721 | 0.73 | GAA (0.53) | VCAM1HTTSMN1; SMN2LMNATSHR | |
| SCHEMBL12115465 | 0.73 | KMT2A (0.47) | HTTSMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL5191089 | 0.72 | CCR5 (0.59) | VCAM1HTTLMNATSHRALDH1A1 | |
| SCHEMBL8251507 | 0.72 | LMNA (0.53) | VCAM1SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL4589053 | 0.69 | CA12 (0.60) | VCAM1HTTSMN1; SMN2LMNATSHR | |
| SCHEMBL3012193 | 0.69 | SIGMAR1 (0.54) | VCAM1HTTSMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163911-B2 | Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-24 | — | — | US | disclosed |