Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 5/20 | 0.54 |
| ▸ | CTSK | P43235 | 5/20 | 0.54 |
| ▸ | CTSS | P25774 | 5/20 | 0.54 |
| ▸ | CTSB | P07858 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGAV | P06756 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20556200 | 1.00 | SIRT2 (0.57) | SIRT2SIRT1FOLH1CTSLCTSK | |
| SCHEMBL27429289 | 0.91 | SIRT2 (0.69) | SIRT2SIRT1FOLH1TGM2ITGB3 | |
| SCHEMBL6946394 | 0.91 | FOLH1 (0.65) | SIRT2SIRT1FOLH1CTSLCTSK | |
| SCHEMBL18063383 | 0.91 | FOLH1 (0.65) | SIRT2SIRT1FOLH1CTSLCTSK | |
| SCHEMBL6560900 | 0.86 | CTSK (0.56) | SIRT2SIRT1CTSLCTSKCTSS | |
| SCHEMBL6560892 | 0.86 | CTSK (0.56) | SIRT2SIRT1CTSLCTSKCTSS | |
| SCHEMBL10561905 | 0.86 | CTSK (0.56) | SIRT2SIRT1CTSLCTSKCTSS | |
| SCHEMBL28832879 | 0.86 | SIRT2 (0.56) | SIRT2SIRT1FOLH1CTSLCTSK | |
| Hydrochloric Acid SCHEMBL1161917 | 0.85 | SIRT2 (0.55) | SIRT2SIRT1FOLH1CTSLCTSK | |
| SCHEMBL1197897 | 0.85 | SYK (0.63) | SIRT2SIRT1FOLH1CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377473-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2024-06-19 | — | — | EP | disclosed |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| CN-108884058-B | Macrocyclic broad spectrum antibiotics | 阿奇克斯制药公司 | 2022-04-29 | — | — | CN | disclosed |
| US-20180327367-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | WUXI APPTEC CO., LTD (CN) | 2018-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180327367-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | SIRT2 3547/4885SIRT1 1447/4885FOLH1 1780/4885 |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | SIRT2 3547/4885SIRT1 1447/4885FOLH1 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.