Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 5/20 | 0.65 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.61 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CPB1 | P15086 | 1/20 | 0.56 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.54 |
| ▸ | ITGAV | P06756 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18063383 | 1.00 | FOLH1 (0.65) | FOLH1SLC1A3SLC1A1LMNASMN1; SMN2 | |
| SCHEMBL11875673 | 0.92 | FOLH1 (0.72) | FOLH1SIRT2SIRT1HTTCPB1 | |
| SCHEMBL4173693 | 0.92 | FOLH1 (0.72) | FOLH1SIRT2SIRT1HTTCPB1 | |
| SCHEMBL4173691 | 0.92 | FOLH1 (0.72) | FOLH1SIRT2SIRT1HTTCPB1 | |
| SCHEMBL4561005 | 0.91 | FOLH1 (0.78) | FOLH1SIRT2SIRT1CPB1CPB2 | |
| SCHEMBL464715 | 0.91 | FOLH1 (0.78) | FOLH1SIRT2SIRT1CPB1CPB2 | |
| SCHEMBL20556201 | 0.91 | SIRT2 (0.57) | FOLH1SLC1A3SLC1A1SIRT2SIRT1 | |
| SCHEMBL20556200 | 0.91 | SIRT2 (0.57) | FOLH1SLC1A3SLC1A1SIRT2SIRT1 | |
| SCHEMBL806151 | 0.91 | FOLH1 (0.78) | FOLH1SIRT2SIRT1CPB1CPB2 | |
| SCHEMBL23574387 | 0.89 | FOLH1 (0.54) | FOLH1SLC1A3SLC1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993571-B2 | Indole derivatives as efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-05-28 | — | — | US | disclosed |
| US-20220194939-A1 | Novel compounds and methods of use treating fructose-related disorders or diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-06-23 | — | — | US | disclosed |
| EP-3955914-A1 | NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES | Colorado Research Partners, LLC (US) | 2022-02-23 | — | — | EP | disclosed |
| US-11180459-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2021-11-23 | — | — | US | disclosed |
| US-20210094912-A1 | INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY (US) | 2021-04-01 | — | — | US | disclosed |
| WO-2020215022-A1 | NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES | COLORADO RESEARCH PARTNERS, LLC (US) | 2020-10-22 | — | — | WO | disclosed |
| US-20200140393-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY (US) | 2020-05-07 | — | — | US | disclosed |
| WO-2018165611-A1 | INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-09-13 | — | — | WO | disclosed |
| WO-2018165612-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-09-13 | — | — | WO | disclosed |
| US-9950993-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-04-24 | — | — | US | disclosed |
| US-5714490-A | 4-(4-(4-(-((5-(2,4-DIHALOPHENYL)--TETRAHYDRO-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)TETRAHYDROFUR-3-YL)METHOXY)PHENYL)-2,4-DIHYDRO-2-(MONO- OR DIHYDROXYALKYL)-3H-1,2,4-TRIAZOL-3-ONE; BROAD SPECTRUM; WATER SOLUBILITY; ASPERGILLUS; CANDIDA | SCHERING CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |
| US-5710154-A | Tetrahydrofuran antifungals | SCHERING CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| US-5703236-A | PROTECTING; REACTING WITH GRIGNARD REAGENT; REDUCTION; CYCLIZATION; DEPROTECTING | SCHERING CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |
| US-5703079-A | Tetrahydrofuran antifungals | SCHERING CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |
| US-5698557-A | Hydroxy-substituted antifungals | SCHERING CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |
| US-5693626-A | TREATING OR PREVENTING FUNGAL INFECTIONS BY ORAL OR PARENTERAL ADMINISTRATION | SCHERING CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |
| US-5661151-A | Tetrahydrofuran antifungals | SCHERING CORPORATION (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0773941-A1 | TETRAHYDROFURAN ANTIFUNGALS | SCHERING CORPORATION (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1997000248-A1 | HYDROXYALKYL-SUBSTITUTED TRIAZOLONES ANTIFUNGALS | SCHERING CORPORATION (US) | 1997-01-03 | — | — | WO | disclosed |
| WO-1996038443-A1 | TETRAHYDROFURAN ANTIFUNGALS | SCHERING CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180459-B2 | Bacterial efflux pump inhibitors | ABCB11, ABCB1, SLC47A1 | FOLH1 1481/4885SLC1A3 942/4885SLC1A1 397/4885 |
| US-20200140393-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, SLC47A1 | FOLH1 1481/4885SLC1A3 942/4885SLC1A1 397/4885 |
| US-20210094912-A1 | INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, ABCG2 | FOLH1 2058/4885SLC1A3 297/4885SLC1A1 122/4885 |
| US-20220194939-A1 | Novel compounds and methods of use treating fructose-related disorders or diseases | GCK, KHK, HK1 | FOLH1 449/4885SLC1A3 930/4885SLC1A1 1484/4885 |
| US-11993571-B2 | Indole derivatives as efflux pump inhibitors | ABCB11, ABCB1, ABCG2 | FOLH1 2058/4885SLC1A3 297/4885SLC1A1 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.