Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178113 | 0.81 | RIPK1 (0.59) | RIPK1NR1H2NR1H3HSP90AA1HSP90AB1 | |
| SCHEMBL25436680 | 0.79 | ALDH1A1 (0.50) | RIPK1NR1H2NR1H3KCNH2 | |
| SCHEMBL26763796 | 0.78 | RIPK1 (0.62) | RIPK1POLBKCNH2HRH3HSP90AA1 | |
| SCHEMBL27504373 | 0.78 | RIPK1 (0.66) | RIPK1NR1H2NR1H3 | |
| SCHEMBL24011067 | 0.76 | RIPK1 (0.68) | RIPK1POLBHSP90AA1HSP90AB1CHRNB2 | |
| SCHEMBL17026995 | 0.76 | RIPK1 (0.67) | RIPK1POLBHSP90AA1HSP90AB1CHRNB2 | |
| SCHEMBL10002512 | 0.73 | RIPK1 (0.64) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL12944008 | 0.73 | RIPK1 (0.63) | RIPK1POLBHSP90AA1HSP90AB1CHRNB2 | |
| SCHEMBL17881870 | 0.72 | RIPK1 (1.00) | RIPK1POLB | |
| SCHEMBL19471151 | 0.72 | RIPK1 (1.00) | RIPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018205948-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-11-15 | — | — | WO | disclosed |