Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | SI | P14410 | 1/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23293519 | 0.98 | GAA (0.54) | GAAMGAMSIMGAM2THRB | |
| SCHEMBL23293481 | 0.95 | GAA (0.54) | GAAMGAMSIMGAM2THRB | |
| SCHEMBL20599579 | 0.84 | ALDH1A1 (0.40) | GAAMGAMSIMGAM2THRB | |
| SCHEMBL20600234 | 0.84 | ALDH1A1 (0.40) | GAAMGAMSIMGAM2THRB | |
| SCHEMBL15647441 | 0.82 | L3MBTL1 (0.48) | GAAMGAMSIMGAM2THRB | |
| SCHEMBL20599636 | 0.82 | MGAM (0.38) | GAAMGAMSIMGAM2THRB | |
| SCHEMBL28771185 | 0.81 | ALDH1A1 (0.44) | THRBATML3MBTL1ALDH1A1TSHR | |
| SCHEMBL21138457 | 0.81 | ALDH1A1 (0.61) | GAATHRBATML3MBTL1ALDH1A1 | |
| SCHEMBL1292196 | 0.81 | ALDH1A1 (0.61) | GAATHRBATML3MBTL1ALDH1A1 | |
| SCHEMBL8710504 | 0.81 | ALDH1A1 (0.61) | GAATHRBATML3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018205948-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-11-15 | — | — | WO | disclosed |