Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24693398 | 1.00 | HSD11B1 (0.41) | HSD11B1KDM1AALDH1A1HSD17B10HPGD | |
| SCHEMBL28526333 | 0.96 | HSD17B10 (0.44) | HSD11B1ALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL28526303 | 0.96 | HSD17B10 (0.44) | HSD11B1ALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL31299297 | 0.92 | ALDH1A1 (0.40) | HSD11B1KDM1AALDH1A1HSD17B10HPGD | |
| SCHEMBL30782216 | 0.90 | HSD11B1 (0.39) | HSD11B1KDM1AALDH1A1HSD17B10HPGD | |
| SCHEMBL25970274 | 0.81 | HSD17B10 (0.46) | HSD11B1KDM1AALDH1A1HSD17B10HPGD | |
| SCHEMBL25983994 | 0.80 | HSD17B10 (0.45) | HSD11B1KDM1AALDH1A1HSD17B10HPGD | |
| SCHEMBL25334904 | 0.79 | HSD17B10 (0.44) | HSD11B1KDM1AALDH1A1HSD17B10HPGD | |
| SCHEMBL31031016 | 0.78 | ALDH1A1 (0.38) | HSD11B1KDM1AALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL22725293 | 0.78 | HSD17B10 (0.48) | HSD11B1ALDH1A1HSD17B10HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018205948-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-11-15 | — | — | WO | disclosed |