Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metribuzin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metribuzin SCHEMBL8535922 | 0.92 | HPGD (0.51) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL66824 | 0.92 | HPGD (0.51) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL20723685 | 0.90 | HPGD (0.50) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL20723898 | 0.90 | HPGD (0.50) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL27754192 | 0.90 | HPGD (0.50) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL11404778 | 0.86 | HPGD (0.53) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL11004013 | 0.86 | HPGD (0.47) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL22715491 | 0.84 | HPGD (0.49) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL27813761 | 0.84 | HPGD (0.46) | HPGDGAAKDM4ELMNAMAPK1 | |
| Metribuzin SCHEMBL368282 | 0.84 | HPGD (0.52) | HPGDGAAKDM4ELMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018213022-A1 | GLUCOSYL TRANSFERASE POLYPEPTIDES AND METHODS OF USE | SYNGENTA PARTICIPATIONS AG (CH) | 2018-11-22 | — | — | WO | disclosed |