Metribuzin

Metribuzin

SCHEMBL8535922

CSc1nnc(C(C)(C)C)c(=O)n1N.CSc1nnc(C(C)(C)C)c(=O)n1N

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.51
GAA P10253 4/20 0.40
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 2/20 0.39
POLB P06746 1/20 0.39
LMNA P02545 3/20 0.38
MAPK1 P28482 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.36
TP53 P04637 2/20 0.36
HTT P42858 2/20 0.36
KMT2A Q03164 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
HSP90AA1 P07900 1/20 0.34
MAPT P10636 1/20 0.34
XBP1 P17861 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metribuzin SCHEMBL66824 1.00 HPGD (0.51) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL27754192 0.98 HPGD (0.50) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL20723685 0.98 HPGD (0.50) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL20723898 0.98 HPGD (0.50) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL11004013 0.93 HPGD (0.47) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL11404778 0.93 HPGD (0.53) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL20564231 0.92 HPGD (0.46) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL22715491 0.92 HPGD (0.49) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL27813761 0.92 HPGD (0.46) HPGDGAAKDM4EALDH1A1POLB
Metribuzin SCHEMBL368282 0.92 HPGD (0.52) HPGDGAAKDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3092310-A1 RNA-GUIDED GENE DRIVES President and Fellows of Harvard College (US) 2016-11-16 EP disclosed
WO-2015105928-A9 RNA-GUIDED GENE DRIVES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-09-24 WO disclosed
WO-2015105928-A1 RNA-GUIDED GENE DRIVES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-07-16 WO disclosed
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
US-5463081-A Chemical intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed
EP-0548264-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES. DU PONT (US) 1993-06-30 EP disclosed
WO-1992020684-A1 HERBICIDAL OXATRICYCLIC ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-26 WO disclosed
WO-1992013845-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-20 WO disclosed
WO-1992010501-A1 HERBICIDAL ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-25 WO disclosed
WO-1992009587-A1 HERBICIDAL OXAZINE ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-11 WO disclosed
WO-1992004827-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-02 WO disclosed
WO-1990002130-A2 HERBICIDES FOR WEED CONTROL IN SUGAR BEETS, OILSEED RAPE AND COLE CROPS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-03-08 WO disclosed
CN-1035033-A Plant promoting agent and the production and the use of the sustained release that sulfonated high polymer applies EXXON CHEMICAL PATENTS INC (US) 1989-08-30 CN disclosed
CN-1034299-A The sulfonated polymer coating of agricultural chemicals EXXON CHEMICAL PATENTS INC (US) 1989-08-02 CN disclosed
WO-1989003638-A1 COATING OF PESTICIDE WITH SULFONATED POLYMERS EXXON CHEMICAL PATENTS, INC. (US) 1989-05-05 WO disclosed
EP-0089313-B1 OXIME ETHERS, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THE OXIME ETHERS AND THEIR USE CIBA-GEIGY AG (CH) 1985-05-02 EP disclosed
US-4511714-A Herbicidal antidote compositions NITROKEMIA IPARTELEPEK (HU) 1985-04-16 US disclosed
EP-0019796-A1 Propionic acid esters, preparation of these compounds, herbicides containing these compounds as active substances, and the use of such compounds and agents for combating weeds F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-12-10 EP disclosed