Metribuzin

Metribuzin

SCHEMBL368282

CC(N)=O.CSc1nnc(C(C)(C)C)c(=O)n1N

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.52
GAA P10253 4/20 0.39
KDM4E B2RXH2 3/20 0.39
LMNA P02545 3/20 0.36
TP53 P04637 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
HTT P42858 2/20 0.36
KMT2A Q03164 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
MAPK1 P28482 2/20 0.34
ALDH1A1 P00352 3/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 2/20 0.33
HSP90AA1 P07900 1/20 0.33
XBP1 P17861 1/20 0.33
HKDC1 Q2TB90 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metribuzin SCHEMBL11404778 0.95 HPGD (0.53) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL66824 0.92 HPGD (0.51) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL20723898 0.90 HPGD (0.50) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL20723685 0.90 HPGD (0.50) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL22715491 0.88 HPGD (0.49) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL11004013 0.86 HPGD (0.47) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL20564231 0.84 HPGD (0.46) HPGDGAAKDM4ELMNATP53
SCHEMBL10439470 0.76 POLB (0.41) HPGDGAAKDM4ESMN1; SMN2KMT2A
Metribuzin SCHEMBL20723628 0.76 HPGD (0.45) HPGDGAAKDM4ELMNATP53
Metribuzin SCHEMBL15152221 0.76 HPGD (0.45) HPGDGAAKDM4ELMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1531670-B1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2015-12-09 EP disclosed
US-8551918-B2 Herbicidal composition SYNGENTA CROP PROTECTION LLC (US) 2013-10-08 US disclosed
US-8097561-B2 Herbicidal composition SYNGENTA CROP PROTECTION, INC. (US) 2012-01-17 US disclosed
US-20070197387-A1 Herbicidal Composition SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 US disclosed
EP-1689227-A2 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2006-08-16 EP disclosed
EP-1531670-A4 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2005-11-23 EP disclosed
US-20050233907-A1 Herbicidal composition SYNGENTA CROP PROTECTION AG (CH) 2005-10-20 US disclosed
WO-2005055716-A2 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2005-06-23 WO disclosed
EP-1531670-A1 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2005-05-25 EP disclosed
WO-2003105587-A1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2003-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050233907-A1 Herbicidal composition ADH5, ADH1C, AQP3 HPGD 880/4885GAA 1060/4885KDM4E 4480/4885
US-20070197387-A1 Herbicidal Composition DDT, HDHD5, DERL1 HPGD 1444/4885GAA 652/4885KDM4E 935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.