Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054692 | 1.00 | CTSK (0.44) | CTSKCTSLCTSBSMN1; SMN2USP2 | |
| SCHEMBL20568411 | 1.00 | CTSK (0.44) | CTSKCTSLCTSBSMN1; SMN2USP2 | |
| SCHEMBL4360723 | 0.88 | ALDH1A1 (0.48) | CTSKCTSLCTSBSMN1; SMN2USP2 | |
| SCHEMBL5354771 | 0.88 | ALDH1A1 (0.48) | CTSKCTSLCTSBSMN1; SMN2USP2 | |
| SCHEMBL30191278 | 0.87 | PADI1 (0.45) | CTSKCTSLCTSBCTSSPADI1 | |
| SCHEMBL30556882 | 0.87 | PADI1 (0.45) | CTSKCTSLCTSBCTSSPADI1 | |
| SCHEMBL10164354 | 0.87 | CTSK (0.43) | CTSKCTSLCTSBSMN1; SMN2USP2 | |
| SCHEMBL5142965 | 0.86 | ALDH1A1 (0.47) | CTSKCTSLCTSBSMN1; SMN2USP2 | |
| SCHEMBL30557002 | 0.86 | PADI1 (0.47) | CTSKCTSLCTSBCTSSPADI1 | |
| Potassium Ion SCHEMBL5142962 | 0.85 | CTSK (0.43) | CTSKCTSLCTSBSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | disclosed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |