Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568416 | 1.00 | DPP4 (0.47) | DPP4ADRB1NR2E1FFAR4NOTUM | |
| SCHEMBL15559068 | 0.90 | ADRB1 (0.49) | DPP4ADRB1NR2E1FFAR4NOTUM | |
| SCHEMBL20040866 | 0.86 | ADRB1 (0.47) | DPP4ADRB1NR2E1FFAR4TSHR | |
| SCHEMBL16904559 | 0.82 | DPP4 (0.46) | DPP4ADRB1NR2E1NOTUM | |
| SCHEMBL16904561 | 0.81 | ADRB1 (0.46) | DPP4ADRB1NR2E1FFAR4NOTUM | |
| SCHEMBL27508461 | 0.81 | ADRB1 (0.46) | DPP4ADRB1NR2E1FFAR4ALDH1A1 | |
| SCHEMBL20040842 | 0.80 | DPP4 (0.44) | DPP4ADRB1NR2E1FFAR4NOTUM | |
| SCHEMBL23113436 | 0.78 | ADRB1 (0.53) | DPP4ADRB1NR2E1FFAR4TSHR | |
| SCHEMBL1603395 | 0.78 | ADRB1 (0.53) | DPP4ADRB1NR2E1FFAR4TSHR | |
| SCHEMBL1420198 | 0.78 | L3MBTL3 (0.50) | DPP4ADRB1NR2E1FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |