Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.60 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.60 |
| ▸ | GCGR | P47871 | 9/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | FRK | P42685 | 2/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504351 | 0.95 | MAPK13 (0.59) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL4721643 | 0.82 | MAPK14 (0.46) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL28904610 | 0.81 | MAPK13 (0.87) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL14691114 | 0.80 | TAAR1 (0.50) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL20567843 | 0.78 | ALOX5 (0.63) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL14692202 | 0.77 | PTGS2 (0.63) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL19868985 | 0.77 | MAPK13 (0.79) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL3760324 | 0.76 | KDM4E (0.73) | MAPK13MAPK12MAPK11MAPK14CYP1A2 | |
| SCHEMBL413667 | 0.76 | MAPK14 (1.00) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL1629037 | 0.75 | MAPK13 (0.85) | MAPK13MAPK12MAPK11MAPK14ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210137884-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2021-05-13 | — | — | US | claimed |
| US-11413272-B2 | Inhibitors of metallo-beta-lactamases | OXFORD UNIVERSITY INNOVATION LIMITED | 2022-08-16 | — | — | US | disclosed |
| EP-3630728-B1 | INHIBITORS OF METALLO-BETA-LACTAMASES | UNIV OXFORD INNOVATION LTD (GB) | 2022-07-27 | — | — | EP | disclosed |
| US-20210137884-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2021-05-13 | — | — | US | disclosed |
| US-20210137884-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2021-05-13 | — | — | US | disclosed |
| EP-3630728-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | Oxford University Innovation Limited (GB) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215799-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11413272-B2 | Inhibitors of metallo-beta-lactamases | MGAM, GAA, ALPI | MAPK13 4471/4885MAPK12 4134/4885MAPK11 3836/4885 |
| US-20210137884-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | MGAM, GAA, ALPI | MAPK13 4471/4885MAPK12 4134/4885MAPK11 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.