Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | HPGD | P15428 | 5/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | GLA | P06280 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | GFER | P55789 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | RAF1 | P04049 | 2/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.57 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119934 | 0.89 | MAPK13 (0.67) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL3120707 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL3120984 | 0.85 | MAPT (0.58) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL3120095 | 0.83 | NOX1 (0.56) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL7143433 | 0.82 | MAPT (0.64) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL15400046 | 0.82 | MAPK13 (0.86) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL1132001 | 0.82 | MAPK13 (0.86) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL1308320 | 0.82 | MAPK13 (0.86) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL8104080 | 0.82 | MAPK13 (0.86) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL4504351 | 0.81 | MAPK13 (0.59) | KDM4EALDH1A1HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187465-B2 | Oxazole tyrosine kinase inhibitors | SAREUM LIMITED (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20150057282-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2015-02-26 | — | — | US | disclosed |
| US-8921544-B2 | Oxazole tyrosine kinase inhibitors | SAREUM LIMITED (GB) | 2014-12-30 | — | — | US | disclosed |
| US-20140275041-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2014-09-18 | — | — | US | disclosed |
| US-20130102592-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2013-04-25 | — | — | US | disclosed |
| US-8378095-B2 | Oxazole tyrosine kinase inhibitors | Saruem Limited (GB) | 2013-02-19 | — | — | US | disclosed |
| US-20100298301-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275041-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | FLT3, AURKA, FLT1 | KDM4E 718/4885ALDH1A1 1403/4885HPGD 4701/4885 |
| US-20100298301-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | FLT3, AURKA, FLT1 | KDM4E 718/4885ALDH1A1 1403/4885HPGD 4701/4885 |
| US-20150057282-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | FLT3, AURKA, FLT1 | KDM4E 718/4885ALDH1A1 1403/4885HPGD 4701/4885 |
| US-20130102592-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | FLT3, AURKA, FLT1 | KDM4E 675/4885ALDH1A1 1431/4885HPGD 4686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.