Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | GLS | O94925 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661255 | 0.76 | GLS (0.62) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL271762 | 0.76 | GLS (0.62) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL5443364 | 0.76 | CYP19A1 (0.56) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL30349578 | 0.76 | CYP19A1 (0.56) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL31743108 | 0.74 | MAT2A (0.48) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL3481105 | 0.74 | CYP19A1 (0.61) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL31036289 | 0.74 | CYP19A1 (0.61) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL11860998 | 0.74 | GLS (0.44) | GLSMAPTALDH1A1CYP1A2POLB | |
| SCHEMBL17576271 | 0.74 | BRPF1 (0.58) | CYP19A1GLSMAPTALDH1A1PKM | |
| SCHEMBL23320466 | 0.73 | CYP19A1 (0.60) | CYP19A1GLSMAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630749-A1 | 2-QUINOLONE DERIVED INHIBITORS OF BCL6 | Cancer Research Technology Limited (GB) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215798-A1 | 2-QUINOLONE DERIVED INHIBITORS OF BCL6 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-11-29 | — | — | WO | disclosed |