Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22543309 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL31741920 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL29774507 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL17240563 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL22542867 | 0.89 | GAA (0.57) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL30754768 | 0.89 | GAA (0.57) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL22542872 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL30754719 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3050610 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL31741919 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630115-B1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIV VIRGINIA PATENT FOUNDATION (US) | 2025-12-10 | — | — | EP | disclosed |
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2024-02-13 | — | — | US | disclosed |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) | 2020-10-15 | — | — | US | disclosed |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) | 2020-10-15 | — | — | US | disclosed |
| EP-3630115-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | University Of Virginia Patent Foundation (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018217757-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | ACAD9, GPR119, NDUFAF1 | SMN1; SMN2 334/4885TP53 3537/4885MAPT 3834/4885 |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | ACAD9, GPR119, NDUFAF1 | SMN1; SMN2 334/4885TP53 3537/4885MAPT 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.