Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571102 | 0.95 | MAP3K8 (0.34) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL30721099 | 0.92 | CYP11B2 (0.35) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL22301636 | 0.92 | CYP11B2 (0.35) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL25636706 | 0.76 | CYP11B2 (0.35) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL23899063 | 0.74 | SRC (0.36) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL19889982 | 0.74 | KHK (0.36) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL28652978 | 0.73 | CSNK2A1 (0.35) | — | |
| SCHEMBL19877263 | 0.72 | CYP11B2 (0.35) | MAP3K8CYP11B2EGFRERBB2 | |
| SCHEMBL19877026 | 0.72 | CYP11B2 (0.36) | MAP3K8CYP11B2EGFR | |
| SCHEMBL20571090 | 0.71 | NR1H2 (0.43) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630746-A1 | COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF CANCER | Araxes Pharma LLC (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018218071-A1 | COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF CANCER | ARAXES PHARMA LLC (US) | 2018-11-29 | — | — | WO | disclosed |