Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 6/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.35 |
| ▸ | MAP3K8 | P41279 | 10/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | PRKACG | P22612 | 1/20 | 0.31 |
| ▸ | PRKACB | P22694 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23899093 | 0.84 | SRC (0.37) | SRCEGFRMAP3K8CSNK1A1CLK4 | |
| SCHEMBL20571102 | 0.78 | MAP3K8 (0.34) | SRCEGFRERBB2MAP3K8CSNK1A1 | |
| SCHEMBL4962416 | 0.76 | GPR35 (0.47) | MAP3K8 | |
| SCHEMBL20570729 | 0.74 | MAP3K8 (0.32) | EGFRERBB2MAP3K8CYP11B2 | |
| SCHEMBL23899035 | 0.72 | EGFR (0.50) | EGFR | |
| SCHEMBL13976998 | 0.72 | EGFR (0.46) | SRCEGFRERBB2 | |
| SCHEMBL29775134 | 0.72 | EGFR (0.46) | SRCEGFRERBB2 | |
| SCHEMBL28685487 | 0.71 | EGFR (0.41) | SRCEGFRERBB2 | |
| SCHEMBL16858509 | 0.71 | SLC22A12 (0.40) | EGFRERBB2CYP3A4 | |
| SCHEMBL30670658 | 0.71 | SLC22A12 (0.40) | EGFRERBB2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021202688-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. (US) | 2021-10-07 | — | — | WO | disclosed |