Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571175 | 0.85 | SIGMAR1 (0.47) | SIGMAR1CYP1A2CYP2D6TMEM97KCNH2 | |
| SCHEMBL20570511 | 0.83 | SIGMAR1 (0.47) | SIGMAR1VEGFAEGLN1CYP1A2CYP2D6 | |
| SCHEMBL16509007 | 0.80 | SMN1; SMN2 (0.49) | VEGFAEGLN1GPR119MEN1KMT2A | |
| SCHEMBL6822757 | 0.77 | VEGFA (0.45) | SIGMAR1VEGFAEGLN1MEN1KMT2A | |
| SCHEMBL21821055 | 0.77 | MAPT (0.48) | CNR1GPR119MEN1KMT2AHTT | |
| SCHEMBL3708001 | 0.76 | HTR2A (0.52) | SIGMAR1KCNH2 | |
| SCHEMBL20570391 | 0.75 | GPR119 (0.47) | GPR119MEN1KMT2A | |
| SCHEMBL2850833 | 0.74 | KDM1A (0.48) | SIGMAR1VEGFAEGLN1GPR119MEN1 | |
| SCHEMBL1332850 | 0.74 | CHRM3 (0.56) | SIGMAR1TMEM97MEN1KMT2AMAPK1 | |
| SCHEMBL17444604 | 0.74 | HRH3 (0.56) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634404-A1 | PYRAZOLE MAGL INHIBITORS | Lundbeck La Jolla Research Center, Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| WO-2018217809-A1 | PYRAZOLE MAGL INHIBITORS | ABIDE THERAPEUTICS, INC. (US) | 2018-11-29 | — | — | WO | disclosed |