SCHEMBL6822757

SCHEMBL6822757

CC(C)(C)OC(=O)N1CCN(CCc2ccc(F)c(F)c2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 1/20 0.45
EGLN1 Q9GZT9 1/20 0.45
CHRM2 P08172 1/20 0.45
CHRM4 P08173 1/20 0.45
CHRM1 P11229 1/20 0.45
CHRM3 P20309 1/20 0.45
ACKR3 P25106 2/20 0.44
DPP4 P27487 1/20 0.44
IDO1 P14902 1/20 0.44
TDO2 P48775 1/20 0.44
IDO2 Q6ZQW0 1/20 0.44
ALDH1A1 P00352 2/20 0.43
PLK1 P53350 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
HTT P42858 2/20 0.42
STS P08842 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2723325 0.87 KCNJ1 (0.53) ACKR3SIGMAR1
SCHEMBL3708001 0.86 HTR2A (0.52) CHRM2CHRM4CHRM1CHRM3PLK1
SCHEMBL20046908 0.82 ACKR3 (0.45) CHRM2CHRM4CHRM1CHRM3ACKR3
SCHEMBL2850833 0.82 KDM1A (0.48) VEGFAEGLN1CHRM2CHRM4CHRM1
SCHEMBL17444604 0.82 HRH3 (0.56) CHRM2CHRM4CHRM1CHRM3ACKR3
SCHEMBL1332850 0.82 CHRM3 (0.56) CHRM3MEN1KMT2ASIGMAR1MAPK1
SCHEMBL4572803 0.81 SIGMAR1 (0.48) VEGFAEGLN1CHRM2CHRM4CHRM1
SCHEMBL22800905 0.81 SIGMAR1 (0.48) VEGFAEGLN1CHRM2CHRM4CHRM1
SCHEMBL2379018 0.81 THRB (0.52) VEGFAEGLN1CHRM2CHRM4CHRM1
SCHEMBL115666 0.81 GPR119 (0.44) VEGFAEGLN1CHRM2CHRM4CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004111052-A1 PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) XENOVA LIMITED (GB) 2004-12-23 WO disclosed
WO-2004065389-A1 PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS MODULATORS OF MULTIDRUG RESISTANCE XENOVA LIMITED (GB) 2004-08-05 WO disclosed