Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21083969 | 0.84 | AKT1 (0.46) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL2144199 | 0.79 | CCR5 (0.47) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL383265 | 0.79 | CCR5 (0.47) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL383264 | 0.79 | CCR5 (0.47) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL20576058 | 0.79 | OPRM1 (0.55) | MEN1KMT2ARAB9AOPRM1GRIN2B | |
| SCHEMBL29856880 | 0.77 | CCR5 (0.46) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL27876478 | 0.77 | CCR5 (0.46) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL31629952 | 0.77 | CCR5 (0.46) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL1965677 | 0.77 | CCR5 (0.46) | CCR5NPSR1KDM4EATMTDP1 | |
| SCHEMBL27987481 | 0.77 | CCR5 (0.47) | CCR5NPSR1KDM4EATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987584-B2 | Heterobicyclic amides as inhibitors of CD38 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-05-21 | — | — | US | disclosed |
| US-20230312586-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-10-05 | — | — | US | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| EP-3630748-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2023-04-19 | — | — | EP | disclosed |
| US-11535621-B2 | Heterobicyclic amides as inhibitors of CD38 | RIBON THERAPEUTICS, INC. (US) | 2022-12-27 | — | — | US | disclosed |
| US-20220251065-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2022-08-11 | — | — | US | disclosed |
| US-20220227730-A1 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2022-07-21 | — | — | US | disclosed |
| US-10961218-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-20210032251-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-02-04 | — | — | US | disclosed |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | CORNELL UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
| WO-2020232401-A1 | COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020232403-A1 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20180346446-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
| US-20210032251-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | CD38, PARP12, ENTPD2 | CCR5 2119/4885NPSR1 2678/4885KDM4E 1792/4885 |
| US-20230312586-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | CD38, PARP12, ENTPD2 | CCR5 2119/4885NPSR1 2678/4885KDM4E 1792/4885 |
| US-20220227730-A1 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS | XBP1, DDIT3, ATF4 | CCR5 1838/4885NPSR1 4204/4885KDM4E 3118/4885 |
| US-11535621-B2 | Heterobicyclic amides as inhibitors of CD38 | CD38, PARP12, ENTPD2 | CCR5 2119/4885NPSR1 2678/4885KDM4E 1792/4885 |
| US-10961218-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
| US-20220251065-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
| US-20180346446-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
| US-11987584-B2 | Heterobicyclic amides as inhibitors of CD38 | CD38, PARP12, ENTPD2 | CCR5 2119/4885NPSR1 2678/4885KDM4E 1792/4885 |
| US-10745379-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | CCR5 4388/4885NPSR1 4669/4885KDM4E 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.