Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20575924 | 1.00 | RIPK1 (0.43) | RIPK1ADORA2BADORA1CDK1SMYD3 | |
| SCHEMBL20576788 | 0.94 | ADORA2B (0.43) | RIPK1ADORA2BADORA1CDK1SMYD3 | |
| SCHEMBL20576791 | 0.94 | ADORA2B (0.43) | RIPK1ADORA2BADORA1CDK1SMYD3 | |
| SCHEMBL20576535 | 0.93 | AXL (0.37) | RIPK1ADORA2BADORA1CDK1CCNT1 | |
| SCHEMBL20576534 | 0.93 | AXL (0.37) | RIPK1ADORA2BADORA1CDK1CCNT1 | |
| SCHEMBL20576607 | 0.93 | RIPK1 (0.41) | RIPK1ADORA2BADORA1SMYD3SYK | |
| SCHEMBL21298686 | 0.93 | RIPK1 (0.41) | RIPK1ADORA2BADORA1SMYD3SYK | |
| SCHEMBL20576605 | 0.93 | RIPK1 (0.41) | RIPK1ADORA2BADORA1SMYD3SYK | |
| SCHEMBL20576599 | 0.93 | RIPK1 (0.41) | RIPK1ADORA2BADORA1SMYD3SYK | |
| SCHEMBL20576566 | 0.92 | ADORA2B (0.43) | RIPK1ADORA2BADORA1CDK1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | claimed |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | claimed |
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392367-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | RIPK1 691/4885ADORA2B 4605/4885ADORA1 4743/4885 |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | RIPK1 691/4885ADORA2B 4605/4885ADORA1 4743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.