Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20576534 | 1.00 | AXL (0.37) | AXLTYRO3MERTKMCHR1ADORA2B | |
| SCHEMBL20576633 | 0.96 | ADORA2B (0.35) | AXLTYRO3MERTKMCHR1ADORA2B | |
| SCHEMBL20576632 | 0.96 | ADORA2B (0.35) | AXLTYRO3MERTKMCHR1ADORA2B | |
| SCHEMBL20576566 | 0.94 | ADORA2B (0.43) | ADORA2BADORA1RIPK1CDK1FLT3 | |
| SCHEMBL20576568 | 0.94 | ADORA2B (0.43) | ADORA2BADORA1RIPK1CDK1FLT3 | |
| SCHEMBL20575926 | 0.93 | RIPK1 (0.43) | AXLTYRO3MERTKMCHR1ADORA2B | |
| SCHEMBL20575924 | 0.93 | RIPK1 (0.43) | AXLTYRO3MERTKMCHR1ADORA2B | |
| SCHEMBL20576582 | 0.92 | MCHR1 (0.36) | MCHR1ADORA2BADORA1HTR1AADRA2A | |
| SCHEMBL20576585 | 0.92 | MCHR1 (0.36) | MCHR1ADORA2BADORA1HTR1AADRA2A | |
| SCHEMBL20576822 | 0.89 | AXL (0.40) | AXLTYRO3MERTKMCHR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | claimed |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | claimed |
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392367-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | AXL 3271/4885TYRO3 4016/4885MERTK 2689/4885 |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | AXL 3271/4885TYRO3 4016/4885MERTK 2689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.