Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CCR4 | P51679 | 2/20 | 0.46 |
| ▸ | EDNRA | P25101 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30634071 | 1.00 | BRD4 (0.50) | BRD4LMNAMAPTPKMCCR4 | |
| SCHEMBL20576018 | 0.80 | GAA (0.49) | BRD4LMNAMAPTPKMEDNRA | |
| SCHEMBL30634069 | 0.80 | GAA (0.49) | BRD4LMNAMAPTPKMEDNRA | |
| SCHEMBL16111175 | 0.73 | PKM (0.57) | LMNAMAPTPKMCCR4EDNRA | |
| SCHEMBL30634095 | 0.73 | CCR4 (0.60) | LMNAMAPTPKMCCR4GAA | |
| SCHEMBL20575835 | 0.73 | CCR4 (0.60) | LMNAMAPTPKMCCR4GAA | |
| SCHEMBL16110825 | 0.71 | ALDH1A1 (0.68) | BRD4LMNAPKMEDNRAGAA | |
| SCHEMBL22034239 | 0.71 | SLC22A12 (0.55) | BRD4LMNAMAPTPKMCCR4 | |
| SCHEMBL22034355 | 0.71 | CCR4 (0.55) | BRD4LMNAMAPTPKMCCR4 | |
| SCHEMBL22034323 | 0.71 | PKM (0.57) | LMNAMAPTPKMCCR4EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479818-B2 | Treatment of fibrosis with IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-11-25 | — | — | US | disclosed |
| EP-3707126-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2025-05-14 | — | — | EP | disclosed |
| US-20240425477-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2024-12-26 | — | — | US | disclosed |
| US-12071424-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2024-08-27 | — | — | US | disclosed |
| CN-111566089-B | IRE1 small molecule inhibitors | 康奈尔大学 | 2023-11-17 | — | — | CN | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-11634403-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2023-04-25 | — | — | US | disclosed |
| US-20220265656-A1 | COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2022-08-25 | — | — | US | disclosed |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | CORNELL UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | CORNELL UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
| WO-2020232401-A1 | COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020232403-A1 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| EP-3707126-A1 | IRE1 SMALL MOLECULE INHIBITORS | Cornell University (US) | 2020-09-16 | — | — | EP | disclosed |
| CN-111566089-A | IRE1 small molecule inhibitor | 康奈尔大学 | 2020-08-21 | — | — | CN | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
| US-20220265656-A1 | COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS | XBP1, DDIT3, ERN2 | BRD4 395/4885LMNA 1752/4885MAPT 3508/4885 |
| US-20240425477-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
| US-11634403-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
| US-12071424-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
| US-12479818-B2 | Treatment of fibrosis with IRE1 small molecule inhibitors | XBP1, DDIT3, HSP90B1 | BRD4 560/4885LMNA 1598/4885MAPT 4228/4885 |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
| US-10745379-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | BRD4 495/4885LMNA 2127/4885MAPT 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.