Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22206164 | 0.79 | NR1H2 (0.42) | L3MBTL1KMT2AMAPT | |
| SCHEMBL28485002 | 0.76 | TUBB4A (0.44) | L3MBTL1KMT2AMAPT | |
| SCHEMBL2090136 | 0.76 | SMARCA2 (0.39) | KMT2AALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3500082 | 0.76 | HDAC1 (0.41) | GPR119MAPTKDM4EGABRA1GABRG2 | |
| SCHEMBL13425981 | 0.76 | PTGS2 (0.46) | ADORA2AADORA1PIK3R1PIK3CAHSD17B10 | |
| SCHEMBL3500812 | 0.75 | TUBB4A (0.55) | HSD17B10GPR119L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL1856174 | 0.75 | SMARCA2 (0.39) | ADORA2AADORA1HSD17B10ALDH1A1ADORA3 | |
| SCHEMBL3502016 | 0.74 | HDAC2 (0.45) | L3MBTL1KMT2AMAPTKDM4E | |
| SCHEMBL2089360 | 0.74 | MAPT (0.52) | L3MBTL1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL2091259 | 0.74 | MAPT (0.42) | L3MBTL1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738033-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-10738033-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-20180346451-A1 | TRK INHIBITION | NANTBIO, INC. | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346451-A1 | TRK INHIBITION | NGFR, NGF, NTRK1 | ADORA2A 2336/4885ADORA1 2428/4885PIK3R1 1615/4885 |
| US-10738033-B2 | Trk inhibition | NGF, NGFR, NTRK2 | ADORA2A 2159/4885ADORA1 2268/4885PIK3R1 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.