SCHEMBL20577

SCHEMBL20577

Nc1nc2nc(Cl)[nH]c2c(=O)[nH]1

nearest known ligand 0.73

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PNP P00491 5/20 0.73
MAPT P10636 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
ALDH1A1 P00352 1/20 0.53
THRB P10828 1/20 0.53
HPGD P15428 1/20 0.53
KMT2A Q03164 1/20 0.53
HSD17B10 Q99714 1/20 0.53
FGFR1 P11362 2/20 0.51
FGFR2 P21802 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29243986 0.90 PNP (0.59) PNPMAPTKDM4EMEN1ALDH1A1
8-Aminoguanine SCHEMBL21761 0.85 PNP (1.00) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL2051361 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL6686388 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL843215 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL22883 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL9116 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL844207 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL843932 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL42760 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1436 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106497-A2 FUNCTIONALIZED CIRCULAR RNA AND METHODS AND INTERMEDIATES FOR THEIR PRODUCTION SIEĆ BADAWCZA ŁUKASIEWICZ – PORT POLSKI OSRODEK ROZWOJU TECHNOLOGII (PL) 2026-05-21 WO claimed
US-20250257360-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER UNIV OKLAHOMA (US) 2025-08-14 US claimed
CN-113151261-B Antisense oligonucleotides as inhibitors of TGF-R signaling 神经视觉医药有限公司 2025-06-17 CN claimed
EP-4504945-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2025-02-12 EP claimed
CN-118931997-A Method for synthesizing adenosine and/or uridine by three-enzyme cascade catalysis 上海飞腾医药科技有限公司 2024-11-12 CN claimed
US-20240294924-A1 ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2024-09-05 US claimed
CN-117795071-A Antisense oligonucleotides for preventing renal dysfunction caused by endothelial dysfunction through inhibition of ephrin-B2 马克斯·普朗克科学促进学会 2024-03-29 CN claimed
EP-4330397-A1 ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2024-03-06 EP claimed
WO-2023196944-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2023-10-12 WO claimed
WO-2022263569-A1 ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2022-12-22 WO claimed
US-5650510-A VIRICIDES OR ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-07-22 US claimed
EP-0398231-B1 Nucleoside analogs ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-07-16 EP claimed
EP-0630381-B1 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-04-09 EP claimed
EP-0269947-B2 Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives ACAD OF SCIENCE CZECH REPUBLIC (CS) 1996-10-16 EP claimed
US-5386030-A Chemical intermediates INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCE OF THE CZECH REPUBLIC (CZ) 1995-01-31 US claimed
EP-0630381-A4 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES. 1995-01-04 EP claimed
EP-0630381-A1 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES. ACAD OF SCIENCE CZECH REPUBLIC (CS) 1994-12-28 EP claimed
US-5208221-A Nucleotides and intermediates for herpes virus or leukemia virus BRISTOL-MYERS SQUIBB COMPANY (US) 1993-05-04 US claimed
WO-1993007157-A1 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OFTHE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1993-04-15 WO claimed
EP-0269947-A1 Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1988-06-08 EP claimed