SCHEMBL843215

SCHEMBL843215

Nc1nc2nc(S)[nH]c2c(=O)[nH]1

nearest known ligand 0.73

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PNP P00491 5/20 0.73
MAPT P10636 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
ALDH1A1 P00352 1/20 0.53
THRB P10828 1/20 0.53
HPGD P15428 1/20 0.53
KMT2A Q03164 1/20 0.53
HSD17B10 Q99714 1/20 0.53
FGFR1 P11362 2/20 0.51
FGFR2 P21802 2/20 0.51
TXN P10599 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Aminoguanine SCHEMBL21761 0.85 PNP (1.00) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL5181913 0.85 PNP (0.48) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL2051361 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL20577 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL843932 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL22883 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL844207 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL9116 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL6686388 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1
SCHEMBL42760 0.76 PNP (0.73) PNPMAPTKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250295658-A1 ANTIPARASITIC AGENTS AND METHODS WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH 2025-09-25 US claimed
CN-119016735-A Gold nanocluster aggregate with multiple stimulus responsivity and preparation method and application thereof 中国科学院苏州纳米技术与纳米仿生研究所 2024-11-26 CN claimed
WO-2023215819-A2 ANTIPARASITIC AGENTS AND METHODS WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2023-11-09 WO claimed
WO-2022160323-A1 APPLICATION OF NUCLEOSIDE ANALOGUE IN PREPARATION OF DRUGS FOR PREVENTING OR TREATING GASTROINTESTINAL DISEASES 兰州大学 2022-08-04 WO claimed
US-20220098262-A1 ANTIBODY-TUMOR NECROSIS FACTOR alpha FUSION PROTEIN AND ITS PREPARATION AND APPLICATIONS DING, Bang (CN) 2022-03-31 US claimed
CN-107603976-B Methods and compositions for RNA-directed target DNA modification and transcriptional regulation 埃玛纽埃尔·沙尔庞捷 2021-10-12 CN claimed
CN-112707921-A Synthesis of fluorescence label of enzyme inhibitor 南京碳硅人工智能生物医药技术研究院有限公司 2021-04-27 CN claimed
WO-2020233723-A1 QUINOLINE DERIVATIVES FOR TREATMENT OF HEAD AND NECK CANCER 正大天晴药业集团股份有限公司 (CN) 2020-11-26 WO claimed
WO-2020118605-A1 ANTIBODY-TUMOR NECROSIS FACTOR-α FUSION PROTEIN, PREPARATION METHOD THEREFOR AND USES THEREOF 丁邦 2020-06-18 WO claimed
CN-109422652-A Application of the salicylic derivative of chloroethene acyloxy in drug 南京大学 2019-03-05 CN claimed
EP-1583842-A4 METHODS FOR THE ELECTROCHEMICAL DETECTION OF MULTIPLE TARGET COMPOUNDS UNIV NORTH CAROLINA (US) 2007-07-04 EP claimed
EP-1583842-A2 METHODS FOR THE ELECTROCHEMICAL DETECTION OF MULTIPLE TARGET COMPOUNDS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-10-12 EP claimed
WO-2003089895-A2 METHODS FOR THE ELECTROCHEMICAL DETECTION OF MULTIPLE TARGET COMPOUNDS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2003-10-30 WO claimed
US-6638494-B1 Iron hydroxide, ferric hydrate, iron oxide, iron mixed oxide or iron; di- or polycarboxylic acid stabilizer; aggregation prevention; antitumor and contrast agents; immune boosters, magnetic resonance imaging, cell fusion, gene transfer PILGRIMM HERBERT (DE) 2003-10-28 US claimed
EP-0888545-B1 SUPER-PARAMAGNETIC PARTICLES WITH INCREASED R 1 RELAXIVITY, PROCESSES FOR PRODUCING SAID PARTICLES AND USE THEREOF PILGRIMM HERBERT (DE) 2002-01-23 EP claimed
US-6242428-B1 NUCLEOSIDES AND NUCLEOSIDE DIMERS CONTAINING AN L-SUGAR IN AT LEAST ONE OF THE NUCLEOSIDES UNISEARCH LIMITED (AU) 2001-06-05 US claimed
EP-1069903-A1 NOVEL NUCLEOSIDE ANALOGS AND USES IN TREATING DISEASE Lipitek International, Inc. (US) 2001-01-24 EP claimed
WO-1999045935-A1 NOVEL NUCLEOSIDE ANALOGS AND USES IN TREATING DISEASE LIPITEK INTERNATIONAL, INC. (US) 1999-09-16 WO claimed
US-5744600-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-04-28 US claimed
EP-0689430-B1 SUPERPARAMAGNETIC PARTICLES, PROCESS FOR PRODUCING THE SAME AND THEIR USE SILICA GEL GMBH (DE) 1997-08-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250295658-A1 ANTIPARASITIC AGENTS AND METHODS DHFR, DHODH, MTHFD1 PNP 29/4885MAPT 3840/4885KDM4E 3659/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.