Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SCN2B | O60939 | 1/20 | 0.46 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20578206 | 1.00 | SCN9A (0.55) | SCN9ASCN5ASCN4ASCN2BSCN1B | |
| SCHEMBL20668562 | 0.90 | SCN9A (0.58) | SCN9ASCN5ASCN4A | |
| SCHEMBL28416267 | 0.90 | SCN9A (0.58) | SCN9ASCN5ASCN4A | |
| SCHEMBL18013377 | 0.87 | SCN9A (0.42) | SCN9A | |
| SCHEMBL20668692 | 0.86 | FPR1 (0.46) | SCN9A | |
| SCHEMBL20578064 | 0.85 | SCN9A (0.55) | SCN9ASCN5ASCN4A | |
| SCHEMBL20578062 | 0.85 | SCN9A (0.55) | SCN9ASCN5ASCN4A | |
| SCHEMBL18013219 | 0.81 | SCN9A (0.61) | SCN9ASCN5ASCN4A | |
| SCHEMBL28388959 | 0.80 | SCN9A (0.56) | SCN9A | |
| SCHEMBL28388958 | 0.80 | SCN9A (0.56) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815197-B2 | N-sulfonyl benzamides as voltage-gated sodium channel inhibitors | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-10-27 | — | — | US | disclosed |
| US-10815197-B2 | N-sulfonyl benzamides as voltage-gated sodium channel inhibitors | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-10-27 | — | — | US | disclosed |
| CN-108430969-B | Heterocyclic substituted N-sulfonyl benzamide derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-06-02 | — | — | CN | disclosed |
| US-20190023654-A1 | N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-01-24 | — | — | US | disclosed |
| US-20190023654-A1 | N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-01-24 | — | — | US | disclosed |
| EP-3412653-A1 | N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2018-12-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815197-B2 | N-sulfonyl benzamides as voltage-gated sodium channel inhibitors | SCN11A, SCN8A, NHERF1 | SCN9A 73/4885SCN5A 9/4885SCN4A 24/4885 |
| US-20190023654-A1 | N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | SLC5A11, SLC6A11, SLC5A1 | SCN9A 1223/4885SCN5A 199/4885SCN4A 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.