Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20580157 | 1.00 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL22210984 | 0.88 | TRPA1 (0.35) | ALDH1A1CYP1A2CYP3A4CYP2C19TRPA1 | |
| SCHEMBL20580703 | 0.88 | TRPA1 (0.35) | ALDH1A1CYP1A2CYP3A4CYP2C19TRPA1 | |
| SCHEMBL22210985 | 0.88 | TRPA1 (0.35) | ALDH1A1CYP1A2CYP3A4CYP2C19TRPA1 | |
| SCHEMBL18921276 | 0.87 | TRPA1 (0.34) | ALDH1A1CYP1A2CYP3A4CYP2C19NR3C2 | |
| SCHEMBL18921274 | 0.87 | TRPA1 (0.34) | ALDH1A1CYP1A2CYP3A4CYP2C19NR3C2 | |
| SCHEMBL29966743 | 0.87 | TRPA1 (0.34) | ALDH1A1CYP1A2CYP3A4CYP2C19NR3C2 | |
| SCHEMBL18921520 | 0.87 | TRPA1 (0.34) | ALDH1A1CYP1A2CYP3A4CYP2C19NR3C2 | |
| SCHEMBL20580690 | 0.85 | RIPK1 (0.50) | ALDH1A1RIPK1HRH3HTT | |
| SCHEMBL20580286 | 0.83 | TACR1 (0.34) | ALDH1A1CYP1A2CYP3A4CYP2C19TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10709692-B2 | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) | DENALI THERAPEUTICS INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-10709692-B2 | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) | DENALI THERAPEUTICS INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20180353480-A1 | ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK1) | APTUIT (VERONA) S.R.L. (IT) | 2018-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180353480-A1 | ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK1) | RIPK1, RIPK2, RIPK3 | ALDH1A1 4555/4885CYP1A2 4790/4885CYP3A4 4586/4885 |
| US-10709692-B2 | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) | RIPK1, RIPK2, RIPK3 | ALDH1A1 4555/4885CYP1A2 4790/4885CYP3A4 4586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.