Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.36 |
| ▸ | INPP5B | P32019 | 1/20 | 0.36 |
| ▸ | INPP5A | Q14642 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845400 | 0.87 | GPR35 (0.51) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL845399 | 0.87 | GPR35 (0.51) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL8085364 | 0.85 | ALDH1A1 (0.53) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL8085366 | 0.85 | ALDH1A1 (0.53) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL845398 | 0.83 | GPR35 (0.50) | GPR35TSHRALDH1A1TDP1HPGD | |
| Hydrochloric Acid SCHEMBL29211442 | 0.81 | GPR35 (0.49) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL11111392 | 0.76 | ALDH1A1 (0.53) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL11111389 | 0.76 | ALDH1A1 (0.53) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL28220465 | 0.76 | GPR35 (0.58) | GPR35TSHRALDH1A1TDP1HPGD | |
| SCHEMBL6136622 | 0.76 | GPR35 (0.57) | GPR35TSHRALDH1A1TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530298-B2 | Poly(phosphoesters) for delivery of nucleic acids | TRANSLATE BIO, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| EP-4047039-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | Translate Bio, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |
| EP-3638716-B1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO INC (US) | 2022-01-05 | — | — | EP | disclosed |
| US-20200277446-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO, INC. | 2020-09-03 | — | — | US | disclosed |
| EP-3638716-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | Translate Bio, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018231709-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO, INC. (US) | 2018-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277446-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | POLR2E, POLR2H, POLR1A | GPR35 4341/4885TSHR 2045/4885ALDH1A1 1556/4885 |
| US-11530298-B2 | Poly(phosphoesters) for delivery of nucleic acids | POLR2E, POLR2H, POLR1A | GPR35 4341/4885TSHR 2045/4885ALDH1A1 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.