Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | YWHAG | P61981 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28793930 | 0.95 | NPC1 (0.63) | NPC1HTTMEN1KMT2ALMNA | |
| Pyrrole SCHEMBL28237296 | 0.92 | NPC1 (0.60) | NPC1HTTMEN1KMT2ALMNA | |
| SCHEMBL3436295 | 0.86 | NPC1 (0.51) | NPC1MEN1KMT2ALMNAMAPT | |
| SCHEMBL6105727 | 0.85 | NPC1 (0.54) | NPC1HTTMEN1KMT2ALMNA | |
| SCHEMBL2612163 | 0.85 | NPC1 (0.54) | NPC1HTTMEN1KMT2ALMNA | |
| SCHEMBL1742844 | 0.84 | ADRB1 (0.59) | NPC1HSD17B10TSHR | |
| SCHEMBL5532619 | 0.83 | NPC1 (0.51) | NPC1MEN1KMT2ALMNAMAPT | |
| SCHEMBL605593 | 0.83 | NPC1 (1.00) | NPC1HTTMEN1KMT2AMAPT | |
| SCHEMBL3083169 | 0.83 | NPC1 (1.00) | NPC1HTTMEN1KMT2AMAPT | |
| SCHEMBL2505914 | 0.82 | NPC1 (0.73) | NPC1HTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11203582-B2 | Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200199094-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2020-06-25 | — | — | US | disclosed |
| WO-2018232264-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2018-12-20 | — | — | WO | disclosed |
| CN-107835806-A | The catalytic hydrogenation of substituted cyanopyridine and the method for preparing the pyridylmethyl benzamide substituted | 拜耳作物科学股份公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-1449493-A | Aminophenoxyacetamide derivatives and pharmaceutical compositions containing them | SUNTORY LTD (JP) | 2003-10-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199094-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | HSPA5, TMBIM6, BAD | NPC1 2297/4885HTT 3558/4885MEN1 4714/4885 |
| US-11203582-B2 | Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress | HSPA5, TMBIM6, BAD | NPC1 2297/4885HTT 3558/4885MEN1 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.