Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 18/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305180 | 0.99 | TLR7 (0.61) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL2058885 | 0.99 | TLR7 (0.61) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL2058820 | 0.98 | TLR7 (0.60) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL12305179 | 0.93 | TLR7 (0.56) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL2058772 | 0.93 | TLR7 (0.59) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL12305271 | 0.92 | TLR7 (0.55) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL12305273 | 0.92 | TLR7 (0.66) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL2058845 | 0.92 | TLR7 (0.71) | TLR7 | |
| SCHEMBL12305272 | 0.92 | TLR7 (0.58) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL12689494 | 0.92 | TLR7 (0.58) | TLR7CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611268-B2 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9611268-B2 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9611268-B2 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20150239888-A1 | MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES, INC. | 2015-08-27 | — | — | US | disclosed |
| US-20150239888-A1 | MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES, INC. | 2015-08-27 | — | — | US | disclosed |
| US-20150239888-A1 | MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES, INC. | 2015-08-27 | — | — | US | disclosed |
| EP-2170888-B1 | PURINE DERIVATIVES AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES INC (US) | 2015-04-22 | — | — | EP | disclosed |
| EP-2170888-B1 | PURINE DERIVATIVES AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES INC (US) | 2015-04-22 | — | — | EP | disclosed |
| US-8993755-B2 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. | 2015-03-31 | — | — | US | disclosed |
| US-8993755-B2 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. | 2015-03-31 | — | — | US | disclosed |
| US-7968544-B2 | Agonists; Treatment of Hepatitis C virus; purine derivatives | GILEAD SCIENCES, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968544-B2 | Agonists; Treatment of Hepatitis C virus; purine derivatives | GILEAD SCIENCES, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20110150836-A1 | METHODS OF TREATING HBV AND HCV INFECTION | GILEAD SCIENCES, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150836-A1 | METHODS OF TREATING HBV AND HCV INFECTION | GILEAD SCIENCES, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| EP-2170888-A1 | PURINE DERIVATIVES AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTOR 7 | Gilead Sciences, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| US-20090047249-A1 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. | 2009-02-19 | — | — | US | disclosed |
| US-20090047249-A1 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. | 2009-02-19 | — | — | US | disclosed |
| US-20090047249-A1 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. | 2009-02-19 | — | — | US | disclosed |
| WO-2009005687-A1 | PURINE DERIVATIVES AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005687-A1 | PURINE DERIVATIVES AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150836-A1 | METHODS OF TREATING HBV AND HCV INFECTION | HAVCR2, PYGL, HMBS | TLR7 337/4885CYP3A4 1179/4885CYP2D6 1801/4885 |
| US-20090047249-A1 | Modulators of toll-like receptor 7 | TLR7, TLR6, TLR3 | TLR7 1/4885CYP3A4 4544/4885CYP2D6 3812/4885 |
| US-20150239888-A1 | MODULATORS OF TOLL-LIKE RECEPTOR 7 | TLR7, TLR6, TLR3 | TLR7 1/4885CYP3A4 4695/4885CYP2D6 4102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.