Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM6A | O15550 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627370 | 0.72 | EGLN2 (0.36) | HAVCR2HSD17B10BRD4TAF1BRPF1 | |
| SCHEMBL20587988 | 0.67 | KDM4E (0.33) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL22071869 | 0.62 | ADORA3 (0.36) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL26476552 | 0.62 | DPP4 (0.33) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL15730362 | 0.60 | ALDH1A1 (0.65) | HSD17B10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22302554 | 0.60 | BRD4 (0.34) | HAVCR2HSD17B10BRD4TAF1BRPF1 | |
| SCHEMBL12012176 | 0.60 | HAVCR2 (0.41) | HAVCR2HSD17B10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL19577292 | 0.59 | CRBN (0.37) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL5510924 | 0.59 | — | — | |
| SCHEMBL439647 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018229683-A1 | 5,6-FUSED-BICYCLIC COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2018-12-20 | — | — | WO | disclosed |