Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440353 | 0.98 | TP53 (0.40) | TP53POLBEPHX1MMP1MMP9 | |
| SCHEMBL9546485 | 0.97 | MMP1 (0.36) | TP53POLBEPHX1DDB1CRBN | |
| SCHEMBL4827446 | 0.82 | MAP3K14 (0.32) | — | |
| SCHEMBL756451 | 0.81 | CRBN (0.38) | DDB1CRBNALDH1A1NPC1TSHR | |
| SCHEMBL4827454 | 0.78 | MAP3K14 (0.32) | DDB1CRBN | |
| SCHEMBL1421996 | 0.77 | CHRM2 (0.39) | TP53POLBSMN1; SMN2 | |
| SCHEMBL4396268 | 0.75 | CRBN (0.35) | DDB1CRBN | |
| SCHEMBL1773976 | 0.75 | CRBN (0.40) | DDB1CRBN | |
| SCHEMBL5288229 | 0.75 | TP53 (0.41) | TP53POLBMMP1MMP9MMP12 | |
| SCHEMBL3949247 | 0.74 | MAP3K14 (0.40) | DDB1CRBNSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018236928-A1 | HEPATITIS C VIRUS NS3/4A PROTEASE INHIBITORS | UNIVERSITY OF MASSACHUSETTS (US) | 2018-12-27 | — | — | WO | disclosed |