Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595274 | 0.98 | TP53 (0.38) | TP53EPHX1POLBMMP1MMP9 | |
| SCHEMBL9546485 | 0.95 | MMP1 (0.36) | TP53EPHX1POLBMMP1MMP9 | |
| SCHEMBL4827446 | 0.81 | MAP3K14 (0.32) | GAA | |
| SCHEMBL756451 | 0.80 | CRBN (0.38) | NPC1TSHRALDH1A1HTTGAA | |
| SCHEMBL1421996 | 0.79 | CHRM2 (0.39) | TP53POLBSMN1; SMN2HTT | |
| SCHEMBL4827454 | 0.76 | MAP3K14 (0.32) | — | |
| SCHEMBL1884135 | 0.76 | ALDH1A1 (0.34) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1892476 | 0.76 | ALDH1A1 (0.34) | MAPTALDH1A1 | |
| SCHEMBL13387598 | 0.74 | EPHX1 (0.60) | EPHX1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8426647 | 0.74 | EPHX1 (0.60) | EPHX1SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027143-A2 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007137080-A2 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2007-11-29 | — | — | WO | disclosed |