Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS2 | Q96GW9 | 7/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20596045 | 0.91 | MARS2 (0.54) | MARS2 | |
| SCHEMBL20595924 | 0.90 | MARS2 (0.66) | MARS2CHEK2PRMT5 | |
| SCHEMBL23391444 | 0.86 | MARS2 (0.40) | MARS2PRKCZCHEK2 | |
| SCHEMBL30145277 | 0.86 | MARS2 (0.40) | MARS2PRKCZCHEK2 | |
| SCHEMBL20595905 | 0.82 | MARS2 (0.56) | MARS2PRKCZMEN1KMT2AKMO | |
| SCHEMBL20596079 | 0.81 | MARS2 (0.68) | MARS2PRMT5 | |
| SCHEMBL20595831 | 0.80 | MARS2 (0.51) | MARS2PRKCZCHEK2PRMT5GRIN2B | |
| SCHEMBL30145327 | 0.78 | MARS2 (0.40) | MARS2CHEK2 | |
| SCHEMBL23391548 | 0.78 | MARS2 (0.40) | MARS2CHEK2 | |
| SCHEMBL23419242 | 0.77 | MARS2 (0.48) | MARS2PRKCZCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018237349-A1 | INHIBITORS OF TYPED 1 METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM | UNIVERSITY OF WASHINGTON (US) | 2018-12-27 | — | — | WO | claimed |