Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | TSPO | P30536 | 2/20 | 0.33 |
| ▸ | SMCHD1 | A6NHR9 | 1/20 | 0.33 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.33 |
| ▸ | AIP | O00170 | 1/20 | 0.33 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.33 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145306 | 0.86 | ABL1 (0.37) | CSF1RRETKITPDGFRAFLT1 | |
| SCHEMBL20596625 | 0.86 | ABL1 (0.37) | CSF1RRETKITPDGFRAFLT1 | |
| SCHEMBL20596510 | 0.84 | LMNA (0.36) | CSF1RRETKITPDGFRAFLT1 | |
| SCHEMBL23419396 | 0.78 | NTRK1 (0.37) | MAPTTP53BRD4ABL1HSP90AA1 | |
| SCHEMBL20595586 | 0.78 | ABL1 (0.41) | KDRMAPTABL1MAPK1PIK3CA | |
| SCHEMBL23419543 | 0.76 | LMNA (0.36) | MAPTHSP90AA1LMNAHSP90AB1ALDH1A1 | |
| SCHEMBL20596538 | 0.74 | LMNA (0.38) | MAPTTP53HSP90AA1LMNAHSP90AB1 | |
| SCHEMBL20595912 | 0.71 | MAP2K4 (0.38) | HSP90AA1LMNAHSP90AB1KCNH2ALDH1A1 | |
| SCHEMBL20595835 | 0.70 | MEN1 (0.38) | MAPTHSP90AA1LMNAHSP90AB1MAPK1 | |
| SCHEMBL20596077 | 0.70 | HSP90AA1 (0.39) | MAPTHSP90AA1CDC7CCNT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | UNIVERSITY OF WASHINGTON (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210155617-A1 | INHIBITORS OF TYPE l METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM | UNIVERSITY OF WASHINGTON | 2021-05-27 | — | — | US | disclosed |
| WO-2018237349-A1 | INHIBITORS OF TYPED 1 METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM | UNIVERSITY OF WASHINGTON (US) | 2018-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | AARS1, EMG1, GARS1 | CSF1R 1692/4885RET 2171/4885KIT 4313/4885 |
| US-20210155617-A1 | INHIBITORS OF TYPE l METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM | AARS1, GARS1, MTR | CSF1R 2415/4885RET 1566/4885KIT 4244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.