Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980580 | 1.00 | DRD1 (0.38) | DRD1ALDH1A1MAPTNPSR1HSD17B10 | |
| SCHEMBL30939542 | 1.00 | DRD1 (0.38) | DRD1ALDH1A1MAPTNPSR1HSD17B10 | |
| SCHEMBL29381475 | 1.00 | DRD1 (0.38) | DRD1ALDH1A1MAPTNPSR1HSD17B10 | |
| SCHEMBL1982377 | 1.00 | DRD1 (0.38) | DRD1ALDH1A1MAPTNPSR1HSD17B10 | |
| SCHEMBL15535915 | 0.92 | DRD1 (0.37) | DRD1ALDH1A1MAPTNPSR1HSD17B10 | |
| SCHEMBL20567334 | 0.92 | NPSR1 (0.39) | ALDH1A1NPSR1HRH3HRH1POLB | |
| SCHEMBL13832581 | 0.90 | ALDH1A1 (0.36) | DRD1ALDH1A1MAPTNPSR1HSD17B10 | |
| SCHEMBL30939529 | 0.88 | POLB (0.34) | DRD1NPSR1MCHR1POLB | |
| SCHEMBL1978383 | 0.88 | POLB (0.34) | DRD1NPSR1MCHR1POLB | |
| SCHEMBL1979013 | 0.88 | AR (0.40) | ALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220071998-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2022-03-10 | — | — | US | disclosed |
| US-11147813-B2 | Modulators of KV3 channels to treat pain | AUTIFONY THERAPEUTICS LIMITED (GB) | 2021-10-19 | — | — | US | disclosed |
| US-20190000848-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2019-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190000848-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | KCNN3, KCNA3, KCND3 | DRD1 2203/4885ALDH1A1 2667/4885MAPT 2772/4885 |
| US-11147813-B2 | Modulators of KV3 channels to treat pain | KCNN3, KCNA3, KCND3 | DRD1 2203/4885ALDH1A1 2667/4885MAPT 2772/4885 |
| US-20220071998-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | KCNN3, KCNA3, KCND3 | DRD1 2354/4885ALDH1A1 2716/4885MAPT 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.