Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23486304 | 0.81 | MAPT (0.56) | MAPTKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL31426894 | 0.81 | KMT2A (0.53) | MAPTKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL486202 | 0.80 | ALDH1A1 (0.52) | MAPTKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL27653513 | 0.80 | ALDH1A1 (0.65) | MAPTKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL27633082 | 0.80 | KMT2A (0.51) | MAPTKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL22557648 | 0.80 | KMT2A (0.47) | MAPTKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL23488258 | 0.79 | NNMT (0.58) | MAPTKMT2ASMN1; SMN2HSD17B10SLC6A3 | |
| SCHEMBL28699641 | 0.78 | NPC1 (0.55) | MAPTKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL31337903 | 0.77 | MAPT (0.52) | MAPTKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL9098351 | 0.76 | KMT2A (0.40) | MAPTKMT2AKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658554-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | North & South Brother Pharmacy Investment Company Limited (CN) | 2020-06-03 | — | — | EP | disclosed |
| WO-2019001396-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-01-03 | — | — | WO | disclosed |