Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17895348 | 0.83 | RAPGEF4 (0.37) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL21388018 | 0.80 | TSHR (0.41) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL29624394 | 0.80 | TSHR (0.41) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL15018736 | 0.78 | RAPGEF4 (0.38) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL28823865 | 0.78 | RAPGEF4 (0.38) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL2656784 | 0.77 | RAPGEF4 (0.37) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL4138945 | 0.75 | RAPGEF4 (0.42) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL31525012 | 0.74 | SMN1; SMN2 (0.32) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL15965543 | 0.73 | L3MBTL1 (0.42) | RAPGEF4TSHRHSD17B10CASP1CASP7 | |
| SCHEMBL10995940 | 0.73 | LMNA (0.44) | RAPGEF4TSHRHSD17B10CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645516-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019001420-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |