Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | KLK1 | P06870 | 2/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
| ▸ | F3 | P13726 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555860 | 0.79 | CES2 (0.56) | CES2CES1KLK1KLK5F2 | |
| Bromide SCHEMBL8428641 | 0.77 | LMNA (0.33) | CES2CES1KLK1KLK5F2 | |
| SCHEMBL28324998 | 0.77 | HPGD (0.44) | CES2CES1F2F10LMNA | |
| Hydrochloric Acid SCHEMBL3647753 | 0.77 | CES2 (0.54) | CES2CES1F2F10PLG | |
| SCHEMBL12569725 | 0.77 | HPGD (0.44) | CES2CES1F2F10PLAU | |
| SCHEMBL9555743 | 0.76 | CES2 (0.54) | CES2CES1LMNAMAP2K2MAP2K1 | |
| SCHEMBL1003016 | 0.76 | CES2 (0.67) | CES2CES1MAP2K2MAP2K1DGAT1 | |
| Hydrochloric Acid SCHEMBL10434081 | 0.76 | CES2 (0.52) | CES2CES1KLK1KLK5F2 | |
| SCHEMBL8131575 | 0.74 | CES2 (0.56) | CES2CES1KLK1KLK5F2 | |
| Hydrochloric Acid SCHEMBL14486951 | 0.74 | LMNA (0.47) | KLK1KLK5F2F10PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645516-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019001420-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |
| CN-101115744-B | Process for preparing 4- (6-chloro-2, 3-methylenedioxyanilino) -7- [2- (4-methylpiperazin-1-yl) ethoxy ] -5-tetrahydropyran-4-yloxyquinazoline, intermediates and crystalline salts thereof | ASTRAZENECA AB (SE) | 2012-02-01 | — | — | CN | disclosed |
| CN-101115744-A | Process for preparing 4- (6-chloro-2, 3-methylenedioxyanilino) -7- [ 2- (4-methylpiperazin-1-yl) ethoxy ] -5-tetrahydropyran-4-yloxyquinazoline, intermediates and crystalline salts thereof | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | CN | disclosed |