Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29233431 | 0.79 | LMNA (0.36) | HIF1AALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL16975276 | 0.74 | F2 (0.41) | ALDH1A1 | |
| SCHEMBL28225623 | 0.69 | L3MBTL1 (0.33) | L3MBTL1 | |
| SCHEMBL20599721 | 0.69 | SMN1; SMN2 (0.39) | L3MBTL1 | |
| SCHEMBL28177518 | 0.69 | — | — | |
| SCHEMBL5647904 | 0.67 | HPGD (0.33) | ALDH1A1HPGD | |
| SCHEMBL5650940 | 0.67 | TP53 (0.42) | CYP1A2CYP2C19 | |
| SCHEMBL28784952 | 0.67 | ELANE (0.36) | ALDH1A1L3MBTL1 | |
| SCHEMBL29233452 | 0.64 | MAPT (0.34) | HIF1AALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL27646906 | 0.64 | NOTUM (0.40) | HIF1AALDH1A1CYP1A2HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645516-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019001420-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |