Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.56 |
| ▸ | EP300 | Q09472 | 2/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.45 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30106400 | 1.00 | IDO1 (0.56) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL13265824 | 0.83 | IDO1 (0.81) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL442916 | 0.83 | IDO1 (0.81) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL225430 | 0.77 | IDO1 (0.68) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL29372744 | 0.77 | IDO1 (0.68) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL2936933 | 0.77 | ALDH1A1 (0.50) | IDO1ALDH1A1MAPK1POLBKDM4E | |
| SCHEMBL11504207 | 0.76 | CYP1A2 (0.62) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL30827114 | 0.76 | CYP1A2 (0.62) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL358976 | 0.75 | ALDH1A1 (0.67) | IDO1ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL31295703 | 0.75 | ALDH1A1 (0.67) | IDO1ALDH1A1MAPK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746283-B2 | Silole and germole fused ring photochromic compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2023-09-05 | — | — | US | disclosed |
| CN-110799514-B | Silole and germacyclopentadiene fused ring photochromic compounds | 光学转变有限公司 | 2023-01-31 | — | — | CN | disclosed |
| EP-3645540-B1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2021-11-03 | — | — | EP | disclosed |
| US-20200172798-A1 | Silole and Germole Fused Ring Photochromic Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-04 | — | — | US | disclosed |
| EP-3645540-A1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-05-06 | — | — | EP | disclosed |
| CN-110799514-A | Silole and germacyclopentadiene fused ring photochromic compounds | 光学转变有限公司 | 2020-02-14 | — | — | CN | disclosed |
| WO-2019001724-A1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, LTD. (IE) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172798-A1 | Silole and Germole Fused Ring Photochromic Compounds | CCNB2, SKP2, CCNB1 | IDO1 1521/4885EP300 2849/4885KAT2B 1019/4885 |
| US-11746283-B2 | Silole and germole fused ring photochromic compounds | CCNB2, SKP2, CCNB1 | IDO1 1521/4885EP300 2849/4885KAT2B 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.