Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20599922 | 0.88 | ALDH1A1 (0.51) | NPC1MAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL4811811 | 0.87 | LMNA (0.47) | NPC1MAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL20599950 | 0.85 | TSHR (0.46) | NPC1MAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL20599916 | 0.84 | PPARA (0.45) | NPC1MAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL20599917 | 0.84 | LMNA (0.43) | NPC1MAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL8982509 | 0.81 | AKR1B1 (0.48) | NPC1MAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL6597874 | 0.79 | MAPT (0.48) | NPC1MAPTALDH1A1MIFL3MBTL1 | |
| SCHEMBL31532269 | 0.78 | ALDH1A1 (0.47) | MAPTALDH1A1MIFL3MBTL1TSHR | |
| SCHEMBL31532270 | 0.78 | ALDH1A1 (0.47) | MAPTALDH1A1MIFL3MBTL1TSHR | |
| SCHEMBL15262082 | 0.77 | NOS2 (0.46) | NPC1MAPTALDH1A1MIFLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019002407-A1 | PROCESS FOR THE PREPARATION OF TIPIRACIL HYDROCHLORIDE | AMNEAL PHARMACEUTICALS COMPANY GMBH (CH) | 2019-01-03 | — | — | WO | disclosed |