Phosphoric Acid

Phosphoric Acid

SCHEMBL20600152

NC(=O)c1[nH]nc2c1ccc1cncnc12.O=P(O)(O)O

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 2/20 0.48
CDK2 P24941 2/20 0.48
CCNA1 P78396 2/20 0.48
RPS6KB1 P23443 7/20 0.34
AKT1 P31749 6/20 0.34
CSNK2A2 P19784 1/20 0.32
CSNK2B P67870 1/20 0.32
PIM1 P11309 1/20 0.30
TTK P33981 1/20 0.30
PIM2 Q9P1W9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1559614 0.95 CCNA2 (0.52) CCNA2CDK2CCNA1RPS6KB1AKT1
Trifluoroacetic Acid SCHEMBL9936775 0.86 CCNA2 (0.45) CCNA2CDK2CCNA1RPS6KB1AKT1
SCHEMBL1558502 0.82 CCNA2 (0.38) CCNA2CDK2CCNA1RPS6KB1AKT1
Hydrochloric Acid SCHEMBL6052921 0.81 CCNA2 (0.37) CCNA2CDK2CCNA1RPS6KB1AKT1
SCHEMBL382261 0.81 EIF2AK4 (0.39) CCNA2CDK2CCNA1CSNK2A2
Phosphoric Acid SCHEMBL20600153 0.79 RPS6KB1 (0.33) CCNA2CDK2CCNA1RPS6KB1AKT1
SCHEMBL2172066 0.74 CCNA2 (0.54) CCNA2CDK2CCNA1
SCHEMBL29377248 0.72 RPS6KB1 (0.36) CCNA2CDK2CCNA1RPS6KB1AKT1
SCHEMBL1559078 0.72 RPS6KB1 (0.36) CCNA2CDK2CCNA1RPS6KB1AKT1
Hydrochloric Acid SCHEMBL1560043 0.71 RPS6KB1 (0.35) CCNA2CDK2CCNA1RPS6KB1AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3645535-A1 NEW SALT OF N-(2,6-DIETHYLPHENYL)-8-({4-[4-(DIMETHYLAMINO)PIPERIDIN-1-YL]-2-METHOXYPHENYL}AM INO)-1-METHYL-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING IT Les Laboratoires Servier SAS (FR) 2020-05-06 EP disclosed
WO-2019002454-A1 NEW SALT OF N-(2,6-DIETHYLPHENYL)-8-({4-[4-(DIMETHYLAMINO)PIPERIDIN-1-YL]-2-METHOXYPHENYL}AM INO)-1-METHYL-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING IT LES LABORATOIRES SERVIER (FR) 2019-01-03 WO disclosed