Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 5/20 | 0.38 |
| ▸ | CDK8 | P49336 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558502 | 0.83 | CCNA2 (0.38) | CCNA2CDK2CCNA1CSNK2A1CSNK2A2 | |
| SCHEMBL1559614 | 0.82 | CCNA2 (0.52) | CCNA2CDK2CCNA1CSNK2A1CSNK2A2 | |
| Hydrochloric Acid SCHEMBL6052921 | 0.82 | CCNA2 (0.37) | CCNA2CDK2CCNA1CSNK2A1CSNK2A2 | |
| Hydrochloric Acid SCHEMBL1560040 | 0.81 | CCNA2 (0.51) | CCNA2CDK2CCNA1CSNK2A1CSNK2A2 | |
| Phosphoric Acid SCHEMBL20600152 | 0.81 | CCNA2 (0.48) | CCNA2CDK2CCNA1CSNK2A2 | |
| SCHEMBL382262 | 0.78 | YTHDC1 (0.45) | CCNCCDK8YTHDC1CSNK2A1MAPT | |
| Trifluoroacetic Acid SCHEMBL9936775 | 0.75 | CCNA2 (0.45) | CCNCCDK8CCNA2CDK2CCNA1 | |
| SCHEMBL666445 | 0.69 | PLK1 (0.50) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL25850566 | 0.67 | EGFR (0.48) | CYP3A4MAPTEGFR | |
| SCHEMBL1558505 | 0.66 | CSNK2A2 (0.35) | CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125822-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-12-02 | — | — | EP | claimed |
| EP-1986632-A1 | COMBINATIONS COMPRISING A CDK INHIBITOR AND A GROWTH FACTOR ANTIBODY OR ANTI-MITOTIC | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-11-05 | — | — | EP | claimed |
| WO-2008074788-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | claimed |
| WO-2007090794-A1 | COMBINATIONS COMPRISING A CDK INHIBITOR AND A GROWTH FACTOR ANTIBODY OR ANTI-MITOTIC | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-08-16 | — | — | WO | claimed |
| EP-2408776-A1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF THYMOMA | Nerviano Medical Sciences S.r.l. (IT) | 2012-01-25 | — | — | EP | disclosed |
| EP-2323664-A1 | USE OF A CDK INHIBITOR FOR THE TREATMENT OF GLIOMA | Nerviano Medical Sciences S.r.l. (IT) | 2011-05-25 | — | — | EP | disclosed |
| EP-2320903-A1 | THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT | Nerviano Medical Sciences S.r.l. (IT) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010012733-A9 | USE OF A CDK INHIBITOR FOR THE TREATMENT OF GLIOMA | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-04-14 | — | — | WO | disclosed |
| WO-2010106028-A1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF THYMOMA | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-09-23 | — | — | WO | disclosed |
| WO-2010012777-A1 | THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-02-04 | — | — | WO | disclosed |
| WO-2010012733-A1 | USE OF A CDK INHIBITOR FOR THE TREATMENT OF GLIOMA | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-02-04 | — | — | WO | disclosed |
| EP-1636236-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104007-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-12-02 | — | — | WO | disclosed |