Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 10/20 | 0.34 |
| ▸ | AKT1 | P31749 | 6/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1559614 | 0.91 | CCNA2 (0.52) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| Hydrochloric Acid SCHEMBL1560040 | 0.90 | CCNA2 (0.51) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| Phosphoric Acid SCHEMBL20600152 | 0.86 | CCNA2 (0.48) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| SCHEMBL1558502 | 0.82 | CCNA2 (0.38) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| Trifluoroacetic Acid SCHEMBL9936778 | 0.81 | L3MBTL1 (0.34) | L3MBTL1RPS6KB1AKT1CSNK2A2CSNK2B | |
| Hydrochloric Acid SCHEMBL6052921 | 0.81 | CCNA2 (0.37) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| SCHEMBL382261 | 0.75 | EIF2AK4 (0.39) | CCNA2CDK2CCNA1CSNK2A2CCNC | |
| SCHEMBL1559078 | 0.72 | RPS6KB1 (0.36) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| SCHEMBL29377248 | 0.72 | RPS6KB1 (0.36) | CCNA2CDK2CCNA1RPS6KB1AKT1 | |
| Trifluoroacetic Acid SCHEMBL28386678 | 0.72 | PARP1 (0.51) | L3MBTL1RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |