SCHEMBL20604684

SCHEMBL20604684

N=C(N)n1c(=O)[nH]c(=O)[nH]c1=O

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TYMP P19971 2/20 0.32
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL252499 0.77 JAK2 (0.32)
Guanidine SCHEMBL27610119 0.72 TYMP (0.38) TYMPKDM4E
SCHEMBL133750 0.69
SCHEMBL27889745 0.69 JAK2 (0.38) TYMPTDP1
SCHEMBL17849940 0.67 JAK2 (0.32) TYMP
Guanidine SCHEMBL22345319 0.65 LMNA (0.36) TYMP
SCHEMBL28705743 0.65 TYMP (0.39) TYMP
SCHEMBL2169311 0.64 DAO (0.41)
SCHEMBL3480363 0.64 ALDH1A1 (0.38) TYMPKDM4ETDP1
SCHEMBL28606 0.64 TYMP (0.31) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190100784-A1 RNA ANALYSIS BY TOTAL HYDROLYSIS CureVac SE (DE) 2019-04-04 US claimed
EP-3423595-A1 RNA ANALYSIS BY TOTAL HYDROLYSIS CureVac AG (DE) 2019-01-09 EP claimed
US-11920174-B2 RNA analysis by total hydrolysis and quantification of released nucleosides CureVac SE (DE) 2024-03-05 US disclosed
US-20190100784-A1 RNA ANALYSIS BY TOTAL HYDROLYSIS CureVac SE (DE) 2019-04-04 US disclosed
EP-3423595-A1 RNA ANALYSIS BY TOTAL HYDROLYSIS CureVac AG (DE) 2019-01-09 EP disclosed